I bought the D850 to replace my D750, based on reviews saying that the D850, with its 47 Mpx sensor, was comparable to medium-frame cameras. Then, I tested them side by side, using the same lens (the 24-70 f/2.8), at the same apertures. I´d take a picture on one, then take the same picture on the other, at ISO 200, then ISO 800, then ISO 1600. One difference is that the D850 has a better color gamut. On an 8 1/2 x 11 size print, a gray sky comes out gray, while for the D750, it leans toward purple. Also, there are more shades of brown. I then made blowups at 22 x 17 (actually 21.76 x 14.5). There were some areas of the print where the D850 shots seemed to have more detail, and even better, a greater range of colors. Aside from that, I could only tell the difference in sharpness, and there was a difference, if I used a 4x magnifier, but there was a difference, although subtle.. But, when I reached ISO 1600, the colors now looked even better than the D750 colors. In all, the D850 seems to be the ultimate full-frame digital camera, and it´s only about 3 oz. heavier than the D750, not as heavy as the top of he line Canons, for instance. The main differences are a greater range of colors, more subtle colors, too. Also, you can shoot the D850 at ISO 1600, and it´s to tell those shots from ISO 200.